HSB may refer to:

• HSB (Sweden), a cooperative housing association
• HSB color space
• HSB Televisión, a Colombian television station
• Bremen University of Applied Sciences (German: Hochschule Bremen)
• Hang Seng Bank, a bank based in Hong Kong
• Hardly Strictly Bluegrass, a music festival in San Francisco, California, United States
• Hartford Steam Boiler Inspection and Insurance Company, an American equipment breakdown insurer
• Harz Narrow Gauge Railways (German: Harzer Schmalspurbahnen), a steam railway in Germany
• Erivan K. Haub School of Business, at Saint Joseph's University in Philadelphia, Pennsylvania, United States
• "Heart-Shaped Box", a Nirvana song
• Heaven Shall Burn, a German extreme metal band
• Helensburgh railway station, in Australia
• Helgeland Sparebank, a Norwegian bank
• Helsby railway station, in England
• Hill Street Blues, a serial police drama
• Humidity Sounder for Brazil, an instrument on the Aqua satellite
• Hunter-Schreger band, a feature of the tooth enamel in mammals
• Upper Sorbian language (ISO 639-2 language code)
• Head Start Bureau, a United States federal government agency which runs the Head Start program
• Hogslop String Band, a bluegrass string group